CAMBRIDGE, Mass., Dec. 07, 2019 (GLOBE NEWSWIRE) -- Unum Therapeutics Inc. (NASDAQ: UMRX), a clinical-stage biopharmaceutical company focused on developing curative cell therapies for cancer, today announced Phase 1 clinical updates for its Antibody-Coupled T cell Receptor (ACTR) engineered T-cell therapies, ACTR707 and ACTR087, in patients with relapsed or refractory CD20+ non-Hodgkin Lymphoma (r/r NHL) at the ASH Annual Meeting, being held December 7-10, in Orlando, FL.
“The clinical data presented at this year’s ASH include updates from the ongoing Phase 1 trial of ACTR707 in combination with rituximab and the completed Phase 1 trial of ACTR087 in combination with rituximab, both conducted in patients with relapsed or refractory CD20+ NHL,” said Jessica Sachs, M.D., Chief Medical Officer of Unum. “The data with ACTR707 at this year’s ASH continue to support further dose-escalation in this Phase 1 trial and provide proof-of-mechanism for the ACTR platform that we are also applying in our lead program, a Phase 1 trial with ACTR707 in combination with trastuzumab in HER2+ solid tumor cancers. Safety data from the Phase 1 trial with ACTR087 presented at this year’s ASH provide learnings that are being applied to ongoing clinical trials with ACTR T cell products.
Poster (#1587) Title: “Preliminary Clinical Results from a Phase 1 Study of ACTR707 in Combination With Rituximab in Subjects with Relapsed or Refractory CD20+ Non-Hodgkin Lymphoma”
|Table 1: ACTR707 Preliminary Phase 1 trial clinical response results in r/r NHL (Cohorts 1-4)|
|Clinical Response (1)||Cohort 1 (n=6)||Cohort 2 (n=3)||Cohort 3 (n=5)||Cohort 4 (n=6)||Cohorts 1-4 (n=20)|
|Complete Response||3||1||2||2||40% (8/20)|
|Partial Response||0||1||2||0||15% (3/20)|
|Stable Disease||0||0||0||1||5% (1/20)|
|Indeterminate Response||1||0||0||0||5% (1/20)|
|Progressive Disease||2||1||1||3||35% (7/20)|
|Overall Response Rate||50% (3/6)||67% (2/3)||80% (4/5)||33% (2/6)||55% (11/20)|
|ACTR707+T cells administered, target per patient (range)||25M (23-38M)||40M (30-50M)||55M (45-55M)||80M (65-100M)|
|(1) Data cutoff as of Nov 2019|
|Table 2: ACTR707 Preliminary Phase 1 trial safety results in r/r NHL (Cohorts 1-4)|
|Safety Event (1)||Cohort 1 (n=6)||Cohort 2 (n=3)||Cohort 3 (n=5)||Cohort 4 (n=6)|
|Severe neurologic events (> Grade 3)||0||0||0||0|
|CRS (any grade)||0||0||0||0|
|(1) Data cutoff as of Nov 2019|
Additional details about the ATTCK-20-03 Phase 1 trial can be found here.
Oral Presentation Title (#244): “A Phase 1 Study of ACTR087 in Combination with Rituximab, in Subjects with Relapsed or Refractory CD20-Positive B-Cell Lymphoma”
Following the decision in 2018 to prioritize ACTR707 over ACTR087 for future development in r/r NHL and solid tumors, Unum completed enrollment in the ATTCK-20-2 trial, a Phase 1, multicenter, open-label, single-arm, dose-escalating trial evaluating ACTR087 in combination with rituximab in patients with r/r CD20+ NHL.
Additional details about the ATTCK-20-2 Phase 1 trial can be found here.
About Unum Therapeutics
Unum Therapeutics is a clinical-stage biopharmaceutical company focused on developing curative cell therapies to treat a broad range of cancer patients. Unum’s novel proprietary technologies include Antibody-Coupled T cell Receptor (ACTR), an autologous engineered T-cell therapy that combines the cell-killing ability of T cells and the tumor-targeting ability of co-administered antibodies to exert potent antitumor immune responses, and Bolt-On Chimeric Receptor (BOXR), designed to improve the functionality of engineered T cells by incorporating a “bolt-on” transgene to overcome resistance of the solid tumor microenvironment to T cell attack. Unum has multiple programs in Phase 1 clinical and preclinical testing, including: ACTR707 used in combination with trastuzumab in adult patients with HER2+ advanced cancer and used in combination with rituximab in adult patients with r/r NHL; and BOXR1030 expressing the GOT2 transgene and targeting GPC3+ solid tumor cancers. The Company is headquartered in Cambridge, MA.
Forward looking Statements
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